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Its strongest genetic-study result is p = 10−9, with 3 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied up to 300,486 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 6.06 z-score lower; p = 1 × 10−9.
Where it sits Chromosome 3, band 3p12.1 — in an intron of CADM2.
How common each version is
AG
KoreanKRGDB
A 0.0% · G 100.0%
Japanese ToMMo
G 100.0%
Vietnamese
A 0.5% · G 99.5%
World gnomAD
A 5.1% · G 94.9%
World 1000 Genomes
A 4.6% · G 95.4%
World TOPMed
A 4.9% · G 95.1%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ATwo copies of the version the research linked to General cognitive ability. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to General cognitive ability. That is a smaller link than two copies.
G/GNo copy of the version the research linked to General cognitive ability. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29844566 · open access
Questions about rs424029
What is rs424029?
rs424029 is a single position in the genome, in or near the CADM2 gene. Published research associates it with general cognitive ability. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs424029 linked to?
On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.
Does having rs424029 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs424029 come from?
GWAS Catalog, Nat Commun 2018, PMID:29844566. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
General cognitive ability (rs424029). MyGeneLog™. https://www.mygenelog.com/variants/rs424029