A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Metabolic traits compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Metabolic traits.
G/GPublished research associates this genotype with typical/baseline likelihood of Metabolic traits — no copies of the reported risk allele.
rs4149081 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with metabolic traits. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs4149081 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs4149081 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4149081 come from?
GWAS Catalog, Nature 2011, PMID:21886157. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.