SLCO1B1 · rs4149071
Where this position leads
Drugs: Statins, Ticagrelor
What the study found
Who was studied 8,809 European ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.29 lower (95% confidence interval 0.24-0.34); p = 4 × 10−26.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-12.
ClinVar record 1234509 NM_006446.5(SLCO1B1):c.1498-89T>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs4149071 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with glycochenodeoxycholate glucuronide (1) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Metabolites 2022, PMID:35050183. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Glycochenodeoxycholate glucuronide (1) levels (rs4149071). MyGeneLog™. https://www.mygenelog.com/variants/rs4149071