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Who was studied 7,891 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.124 higher (95% confidence interval 0.088-0.16); p = 2 × 10−11.
How common The G allele had a frequency of about 23% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
A/ANo copy of the version the research linked to Lithocholate sulfate (1) levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Lithocholate sulfate (1) levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Lithocholate sulfate (1) levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4149051 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with lithocholate sulfate (1) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs4149051 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs4149051 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4149051 come from?
GWAS Catalog, Nature genetics 2023, PMID:36635386. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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