Standard

Urate levels

ABCG2 · rs4148155

Where this position leads

Condition: Gout

Drug: Statins

rs4148155 Condition: Gout Gout Condition Drug: Statins Statins Drug rs4148155 rs4148155 ABCG2

What the study found

Who was studied 8,868 Japanese ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.121 higher (95% confidence interval 0.09-0.152); p = 1 × 10−13.

How common The G allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 4, band 4q22.1 — in an intron of ABCG2.

What each result means

A/A No copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Urate levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4148155

What is rs4148155?

rs4148155 is a single position in the genome, in or near the ABCG2 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4148155 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does rs4148155 affect how medicines work?

ABCG2 carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs4148155 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4148155 come from?

GWAS Catalog, Nat Genet 2010, PMID:20139978. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urate levels (rs4148155). MyGeneLog™. https://www.mygenelog.com/variants/rs4148155

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