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Who was studied 80,724 European ancestry cases, 748,975 European ancestry controls.
The effect
Each copy of the A allele carried 0.92 times the odds of Lumbar disc herniation (95% confidence interval 0.89-0.94); p = 1 × 10−10.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 3, band 3p21.31 — in an intron of CACNA2D2.
What each result means
A/ATwo copies of the version the research linked to Lumbar disc herniation. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Lumbar disc herniation. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Lumbar disc herniation. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39511132 · open access
Questions about rs41308273
What is rs41308273?
rs41308273 is a single position in the genome, in or near the CACNA2D2 gene. Published research associates it with lumbar disc herniation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs41308273 linked to?
On MyGeneLog this position is linked to Lumbar Disc Herniation. The research behind each link, and its sources, are set out on that condition page.
Does having rs41308273 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs41308273 come from?
GWAS Catalog, Nature communications 2024, PMID:39511132. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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