Gene Knowledge Graph
UTC
Sensitive

Systemic sclerosis

FLNB · rs4076852

Where this position leads

Condition: Systemic Sclerosis

rs4076852 Condition: Systemic Sclerosis Systemic Sclerosis Condition rs4076852 rs4076852 FLNB

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Systemic sclerosis — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic sclerosis.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic sclerosis compared to the general population.
Source
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
López-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeón CP, Carreira P, Ortego-Centeno N, Castellvi I
and 30 more — show all
Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B, Proudman S, Stevens W, Nikpour M, Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J
European Scleroderma Group† · Australian Scleroderma Interest Group (ASIG)
Nature communications · 2019 · PMID 31672989 · open access

Questions about rs4076852

What is rs4076852?

rs4076852 is a single position in the genome, in or near the FLNB gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4076852 linked to?

On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs4076852 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4076852 come from?

GWAS Catalog, Nat Commun 2019, PMID:31672989. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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