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Type 2 diabetes

INS-IGF2 · rs3842770

Where this position leads

Condition: Type 2 Diabetes

rs3842770 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs3842770 rs3842770 INS-IGF2

What the study found

Who was studied 8,284 African American cases, 15,543 African American controls; replicated in 6,061 African American cases, 5,483 African American controls, 8,130 European ancestry cases, 38,987 European ancestry controls.

The effect Each copy of the A allele carried 1.14 times the odds of Type 2 diabetes (95% confidence interval 1.09-1.19); p = 3 × 10−8.

How common The A allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 11, band 11p15.5 — in an intron of IGF2.

What each result means

A/A Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Source
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes
Ng MC, Shriner D, Chen BH, Li J, Chen WM, Guo X, Liu J, Bielinski SJ, Yanek LR, Nalls MA, Comeau ME, Rasmussen-Torvik LJ
and 75 more — show all
Jensen RA, Evans DS, Sun YV, An P, Patel SR, Lu Y, Long J, Armstrong LL, Wagenknecht L, Yang L, Snively BM, Palmer ND, Mudgal P, Langefeld CD, Keene KL, Freedman BI, Mychaleckyj JC, Nayak U, Raffel LJ, Goodarzi MO, Chen YD, Taylor HA Jr, Correa A, Sims M, Couper D, Pankow JS, Boerwinkle E, Adeyemo A, Doumatey A, Chen G, Mathias RA, Vaidya D, Singleton AB, Zonderman AB, Igo RP Jr, Sedor JR, Kabagambe EK, Siscovick DS, McKnight B, Rice K, Liu Y, Hsueh WC, Zhao W, Bielak LF, Kraja A, Province MA, Bottinger EP, Gottesman O, Cai Q, Zheng W, Zheng W, Blot WJ, Lowe WL, Pacheco JA, Crawford DC, Grundberg E, Rich SS, Hayes MG, Shu XO, Loos RJ, Borecki IB, Peyser PA, Cummings SR, Psaty BM, Fornage M, Iyengar SK, Evans MK, Becker DM, Kao WH, Wilson JG, Rotter JI, Sale MM, Liu S, Rotimi CN, Bowden DW
FIND Consortium · eMERGE Consortium · DIAGRAM Consortium · MuTHER Consortium · MEta-analysis of type 2 DIabetes in African Americans Consortium
PLoS genetics · 2014 · PMID 25102180 · open access

Questions about rs3842770

What is rs3842770?

rs3842770 is a single position in the genome, in or near the INS-IGF2 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3842770 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs3842770 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3842770 come from?

GWAS Catalog, PLoS genetics 2014, PMID:25102180. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs3842770). MyGeneLog™. https://www.mygenelog.com/variants/rs3842770

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