Who was studied 118,811 European ancestry cases, 327,427 European ancestry controls, 127,552 cases, 233,763 controls; replicated in 414,055 European ancestry cases, 892,299 European ancestry controls.
The effect
Each copy of the T allele carried 1.03 times the odds of Depression (95% confidence interval 1.024-1.036); p = 2 × 10−26.
How common The T allele had a frequency of about 81% in the people studied.
Where it sits Chromosome 7, band 7p22.3 — in an intron of MAD1L1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Depression — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depression.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depression compared to the general population.
rs3823624 is a single position in the genome, in or near the MAD1L1 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3823624 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs3823624 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3823624 come from?
GWAS Catalog, Nat Neurosci 2019, PMID:30718901. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.