Type 2 diabetes
SLC30A8 · rs3802177
Where this position leads
Condition: Type 2 Diabetes
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 2,112 lean type 2 diabetes cases, 4,123 obese type 2 diabetes cases, 54,412 controls; replicated in 2,881 lean type 2 diabetes cases, 8,702 obese type 2 diabetes cases, 18,957 controls.
The effect Each copy of the G allele carried 1.23 times the odds of Type 2 diabetes (95% confidence interval 1.15-1.33); p = 4 × 10−8.
How common The G allele had a frequency of about 68% in the people studied.
Where it sits Chromosome 8, band 8q24.11 — in the 3′ untranslated region of SLC30A8.
What each result means
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
In the news
2026-05-22 · Sinnott-Armstrong N, et al., Nature Communications 2026, PMID:42173832
Genetic variants affect diurnal glucose levels throughout the day
Circadian rhythms regulate glucose metabolism as well as sleep, but which genetic variants govern the timing of glucose had not been examined. Using the time of day each blood sample was taken, this study of about 420,000 UK Biobank participants — replicated in the Estonian Biobank, FinnGen, the VA Million Veteran Program and the MGB Biobank — shows that glucose levels are under diurnal genetic control. The two robust time-dependent signals are at MTNR1B, the melatonin receptor (rs10830963), and at CRY2, a core circadian clock gene (rs12419690). Sleep modulated glucose levels, the variants acted independently of sleep, they independently changed the risk of type 2 diabetes, and sleep medications including melatonin were associated with type 2 diabetes. Those two headline positions are not on this site yet; 21 other positions from the study are, among them rs560887 (G6PC2), rs34872471 (TCF7L2), rs3802177 (SLC30A8) and rs11708067 (ADCY5). PMID:42173832.
From our blog
Questions about rs3802177
What is rs3802177?
rs3802177 is a single position in the genome, in or near the SLC30A8 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3802177 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs3802177?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (6 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs3802177 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3802177 come from?
GWAS Catalog, PLoS Genet 2012, PMID:22693455. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs3802177). MyGeneLog™. https://www.mygenelog.com/variants/rs3802177