0 91125Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,113 African American or Afro-Caribbean cases, 117,948 African American or Afro-Caribbean controls, 7,129 European ancestry cases, 439,835 European ancestry controls, 1,066 Hispanic or Latin American cases, 58,199 Hispanic or Latin American controls.
The effect
Each copy of the A allele shifted the measure 0.454 lower (95% confidence interval 0.39-0.52); p = 7 × 10−18.
How common The A allele had a frequency of about 99% in the people studied.
Where it sits Chromosome 8, band 8q11.23 — in an intron of PCMTD1.
What each result means
A/ATwo copies of the version the research linked to Primary angle-closure glaucoma (PheCode 365.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Primary angle-closure glaucoma (PheCode 365.2). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Primary angle-closure glaucoma (PheCode 365.2). This is the starting point the study compared everyone against.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs374522377
What is rs374522377?
rs374522377 is a single position in the genome, in or near the PCMTD1 gene. Published research associates it with primary angle-closure glaucoma (phecode 365.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs374522377 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs374522377 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs374522377 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 91125Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others5Total9Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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