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Fluid intelligence

SULT1A2 · rs3743963

Where this position leads

Condition: Intelligence

rs3743963 Condition: Intelligence Intelligence Condition rs3743963 rs3743963 SULT1A2

What the study found

Who was studied 182,798 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0206 higher; p = 2 × 10−10.

How common The A allele had a frequency of about 46% in the people studied.

Where it sits Chromosome 16, band 16p11.2 — in an intron of SULT1A2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Fluid intelligence compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Fluid intelligence.
G/G Published research associates this genotype with typical/baseline likelihood of Fluid intelligence — no copies of the reported risk allele.
Source
Shared genetic architecture between the topology of brain white matter structural connectome and fluid intelligence
Dong X, Huang W, Chen HJ, Zhang Y, Liu B, Zhang D, Zhang Z, Ma G, Shu N
Communications biology · 2026 · PMID 42092107 · open access

Questions about rs3743963

What is rs3743963?

rs3743963 is a single position in the genome, in or near the SULT1A2 gene. Published research associates it with fluid intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3743963 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs3743963 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3743963 come from?

GWAS Catalog, Communications biology 2026, PMID:42092107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fluid intelligence (rs3743963). MyGeneLog™. https://www.mygenelog.com/variants/rs3743963

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