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Intraocular pressure

SH3PXD2A · rs3740471

Where this position leads

Condition: Glaucoma

rs3740471 Condition: Glaucoma Glaucoma Condition rs3740471 rs3740471 SH3PXD2A

What the study found

Who was studied 115,486 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0954 higher (95% confidence interval 0.063-0.128); p = 1 × 10−8.

How common The T allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 10, band 10q24.33 — a synonymous change in SH3PXD2A.

What each result means

C/C No copy of the version the research linked to Intraocular pressure. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Intraocular pressure. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Intraocular pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs3740471

What is rs3740471?

rs3740471 is a single position in the genome, in or near the SH3PXD2A gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3740471 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs3740471 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3740471 come from?

GWAS Catalog, Hum Mol Genet 2018, PMID:29617998. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intraocular pressure (rs3740471). MyGeneLog™. https://www.mygenelog.com/variants/rs3740471

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