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Macular degeneration

HTRA1-AS1 · rs36212732

Where this position leads

Condition: Age-Related Macular Degeneration

rs36212732 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs36212732 rs36212732 HTRA1-AS1

What the study found

Who was studied 17,289 European ancestry cases, 298,379 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.437 lower (95% confidence interval 0.41-0.46); p = 6 × 10−239.

How common The A allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 10, band 10q26.13 — in an intron of HTRA1-AS1.

What each result means

A/A Two copies of the version the research linked to Macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Macular degeneration. That is a smaller link than two copies.
G/G No copy of the version the research linked to Macular degeneration. This is the starting point the study compared everyone against.
Source

Questions about rs36212732

What is rs36212732?

rs36212732 is a single position in the genome, in or near the HTRA1-AS1 gene. Published research associates it with macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs36212732 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs36212732 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs36212732 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Macular degeneration (rs36212732). MyGeneLog™. https://www.mygenelog.com/variants/rs36212732

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