SEC16A · rs35857370
Where this position leads
Condition: Age-Related Macular Degeneration
Strength of the evidence
Its strongest genetic-study result is p = 10−23, with 4 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 98,316 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.119 higher (95% confidence interval 0.079-0.159); p = 4 × 10−9.
How common The A allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 9, band 9q34.3 — in an intron of SEC16A.
How common each version is
AG
A 6.1% · G 93.9%
A 5.6% · G 94.4%
A 13.2% · G 86.8%
A 5.7% · G 94.3%
A 21.0% · G 79.0%
A 15.3% · G 84.7%
A 20.3% · G 79.7%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs35857370 is a single position in the genome, in or near the SEC16A gene. Published research associates it with triglycerides to total lipids in very large vldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Triglycerides to Total Lipids in Very Large VLDL percentage (rs35857370). MyGeneLog™. https://www.mygenelog.com/variants/rs35857370