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LGALS7 or LGALS7B protein levels

RYR1 · rs35648526

Where this position leads

Condition: Celiac Disease

Drug: Volatile anaesthetics and succinylcholine

rs35648526 Condition: Celiac Disease Celiac Disease Condition Drug: Volatile anaesthetics and succinylcholine Volatile anaesthetics and succinylcholine Drug rs35648526 rs35648526 RYR1

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0825 lower (95% confidence interval 0.056-0.109); p = 8 × 10−12.

How common The G allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 19, band 19q13.2 — in an intron of RYR1.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-06-19. ClinVar record 677415 NM_000540.3(RYR1):c.8817-63A>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version the research linked to LGALS7 or LGALS7B protein levels. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to LGALS7 or LGALS7B protein levels. That is a smaller link than two copies.
G/G Two copies of the version the research linked to LGALS7 or LGALS7B protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs35648526

What is rs35648526?

rs35648526 is a single position in the genome, in or near the RYR1 gene. Published research associates it with lgals7 or lgals7b protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35648526 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does rs35648526 affect how medicines work?

RYR1 carries pharmacogenomic findings for Volatile anaesthetics and succinylcholine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs35648526 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35648526 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

LGALS7 or LGALS7B protein levels (rs35648526). MyGeneLog™. https://www.mygenelog.com/variants/rs35648526

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