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Who was studied 450,243 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.036 lower (95% confidence interval 0.024-0.048); p = 4 × 10−9.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 19, band 19q13.2 — a missense change in RYR1.
What each result means
C/CNo copy of the version the research linked to Appendicular lean mass. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Appendicular lean mass. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Appendicular lean mass. That is the strongest link of the three results. A link in a study is not a diagnosis.
Communications biology · 2020 · PMID 33097823 · open access
Questions about rs34934920
What is rs34934920?
rs34934920 is a single position in the genome, in or near the RYR1 gene. Published research associates it with appendicular lean mass. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs34934920 affect how medicines work?
RYR1 carries pharmacogenomic findings for Volatile anaesthetics and succinylcholine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs34934920 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34934920 come from?
GWAS Catalog, Communications biology 2020, PMID:33097823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 523Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Appendicular lean mass (rs34934920). MyGeneLog™. https://www.mygenelog.com/variants/rs34934920