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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0279 lower (95% confidence interval 0.019-0.037); p = 1 × 10−11.
How common The T allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 19, band 19q13.2 — in an intron of RYR1.
What each result means
G/GNo copy of the version the research linked to Standing height (UKB data field 50). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Standing height (UKB data field 50). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Standing height (UKB data field 50). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs34853245
What is rs34853245?
rs34853245 is a single position in the genome, in or near the RYR1 gene. Published research associates it with standing height (ukb data field 50). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34853245 linked to?
On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.
Does rs34853245 affect how medicines work?
RYR1 carries pharmacogenomic findings for Volatile anaesthetics and succinylcholine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs34853245 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34853245 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1129Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others9Total11Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Standing height (UKB data field 50) (rs34853245). MyGeneLog™. https://www.mygenelog.com/variants/rs34853245