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Feeling fed-up

TBC1D21 · rs34641928

Where this position leads

Condition: Irritable Mood

rs34641928 Condition: Irritable Mood Irritable Mood Condition rs34641928 rs34641928 TBC1D21

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling fed-up compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling fed-up.
G/G Published research associates this genotype with typical/baseline likelihood of Feeling fed-up — no copies of the reported risk allele.
Source
Item-level analyses reveal genetic heterogeneity in neuroticism
Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Nature communications · 2018 · PMID 29500382 · open access

Questions about rs34641928

What is rs34641928?

rs34641928 is a single position in the genome, in or near the TBC1D21 gene. Published research associates it with feeling fed-up. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34641928 linked to?

On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.

Does having rs34641928 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34641928 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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