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Who was studied 367,725 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 8.25 z score lower; p = 2 × 10−16.
How common The T allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 11, band 11p15.3 — between genes, 28.2 kb from BMAL1.
What each result means
C/CNo copy of the version the research linked to Worry too long after an embarrassing experience. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Worry too long after an embarrassing experience. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Worry too long after an embarrassing experience. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 29500382 · open access
Questions about rs34588274
What is rs34588274?
rs34588274 is a single position in the genome, in or near the ARNTL gene. Published research associates it with worry too long after an embarrassing experience. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34588274 linked to?
On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.
Does having rs34588274 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34588274 come from?
GWAS Catalog, Nature communications 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 151239Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)0Others9Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Worry too long after an embarrassing experience (rs34588274). MyGeneLog™. https://www.mygenelog.com/variants/rs34588274