TYK2 · rs34536443
Where this position leads
Condition: Type 1 Diabetes
What the study found
Who was studied 6,683 European ancestry cases, 12,173 European ancestry controls, 2,601 European ancestry affected sibling pair families, 69 European ancestry trios.
The effect Each copy of the G allele carried 1.49 times the odds of Type 1 diabetes (95% confidence interval -); p = 4 × 10−15.
How common The G allele had a frequency of about 96% in the people studied.
Where it sits Chromosome 19, band 19p13.2 — a missense change in TYK2.
What ClinVar records
Classification
Benign/Likely benign for Immunodeficiency 35; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 9 submitters), last evaluated 2026-02-04.
ClinVar record 137869 NM_003331.5(TYK2):c.3310C>G (p.Pro1104Ala)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs34536443 is a single position in the genome, in or near the TYK2 gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2015, PMID:25751624. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs34536443). MyGeneLog™. https://www.mygenelog.com/variants/rs34536443