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Who was studied 251 European ancestry whole-genome sequenced cases, 5,357 European ancestry cases, 13,957 European ancestry whole-genome sequenced controls, 746,129 European ancestry controls.
The effect
Each copy of the G allele carried 1.56 times the odds of Chronic rhinosinusitis (95% confidence interval 1.33-1.82); p = 1 × 10−8.
How common The G allele had a frequency of about 99% in the people studied.
Where it sits Chromosome 17, band 17p13.2 — a missense change in ALOX15.
What ClinVar records
ClassificationBenign for Asthma, nasal polyps, and aspirin intolerance; criteria provided, single submitter (1 of 4 stars, 2 submitters).
ClinVar record 624559NM_001140.5(ALOX15):c.1679C>T (p.Thr560Met)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Chronic rhinosinusitis. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Chronic rhinosinusitis. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Chronic rhinosinusitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs34210653 is a single position in the genome, in or near the ALOX15 gene. Published research associates it with chronic rhinosinusitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34210653 linked to?
On MyGeneLog this position is linked to Chronic Rhinosinusitis and the Bitter Taste Receptor, Chronic Rhinosinusitis with Nasal Polyps. The research behind each link, and its sources, are set out on that condition page.
Does having rs34210653 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34210653 come from?
GWAS Catalog, Nat Genet 2019, PMID:30643255. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 5032136223226Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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