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Who was studied 9,179 European ancestry cases, 134,471 European ancestry controls, 1,983 East Asian ancestry cases, 13,719 East Asian ancestry controls, 127 Sub-Saharan African ancestry cases, 100 Sub-Saharan African ancestry controls.
The effect
Each copy of the T allele carried 1.16 times the odds of Glaucoma (primary open-angle) (95% confidence interval 1.11-1.21); p = 3 × 10−9.
Where it sits Chromosome 22, band 22q11.21 — in an intron of TXNRD2.
What each result means
C/CNo copy of the version the research linked to Glaucoma (primary open-angle). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Glaucoma (primary open-angle). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Glaucoma (primary open-angle). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33627673 · open access
Questions about rs34175429
What is rs34175429?
rs34175429 is a single position in the genome, in or near the TXNRD2 gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34175429 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs34175429 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34175429 come from?
GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1512111Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others11Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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