Standard

Glaucoma

TXNRD2 · rs33997573

Where this position leads

Condition: Glaucoma

rs33997573 Condition: Glaucoma Glaucoma Condition rs33997573 rs33997573 TXNRD2

What the study found

Who was studied 38,064 African American or Afro-Caribbean cases, 76,856 African American or Afro-Caribbean controls, 11,570 Hispanic or Latin American cases, 45,339 Hispanic or Latin American controls, 1,446 East Asian ancestry cases, 5,057 East Asian ancestry controls, 81,303 European ancestry cases, 349,418 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0708 higher (95% confidence interval 0.055-0.087); p = 1 × 10−20.

How common The C allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 22, band 22q11.21 — in an intron of TXNRD2.

What each result means

C/C Two copies of the version the research linked to Glaucoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Glaucoma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Glaucoma. This is the starting point the study compared everyone against.
Source

Questions about rs33997573

What is rs33997573?

rs33997573 is a single position in the genome, in or near the TXNRD2 gene. Published research associates it with glaucoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs33997573 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs33997573 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs33997573 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glaucoma (rs33997573). MyGeneLog™. https://www.mygenelog.com/variants/rs33997573

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