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Age-related macular degeneration

near TGFBR1 · rs334362

Where this position leads

Condition: Age-Related Macular Degeneration

rs334362 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs334362 rs334362 near TGFBR1

What the study found

Who was studied 57,290 European ancestry cases, 324,430 European ancestry controls, 2,302 African American cases, 29,223 African American controls, 1,656 Hispanic or Latin American cases, 10,819 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 0.0748 higher (95% confidence interval 0.057-0.092); p = 5 × 10−17.

How common The A allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 9, band 9q22.33 — between genes, 10.1 kb from TGFBR1.

What each result means

A/A Two copies of the version the research linked to Age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Age-related macular degeneration. That is a smaller link than two copies.
G/G No copy of the version the research linked to Age-related macular degeneration. This is the starting point the study compared everyone against.
Source

Questions about rs334362

What is rs334362?

rs334362 is a single position in the genome, in or near the near TGFBR1 gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs334362 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs334362 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs334362 come from?

GWAS Catalog, Nature genetics 2024, PMID:39623103. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Age-related macular degeneration (rs334362). MyGeneLog™. https://www.mygenelog.com/variants/rs334362

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