Sensitive

Cutaneous lupus erythematosus

FLOT1 · rs3131060

Where this position leads

Condition: Cutaneous Lupus Erythematosus

What the study found

Who was studied 151 European ancestry cases, 1,288 European ancestry controls; replicated in 219 European ancestry cases, 262 European ancestry controls.

The effect Each copy of the A allele carried 2.30 times the odds of Cutaneous lupus erythematosus (95% confidence interval 1.71-3.11); p = 1 × 10⁻¹³.

How common The A allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 2.2 kb from LINC00243.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cutaneous lupus erythematosus compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cutaneous lupus erythematosus.

G/G Published research associates this genotype with typical/baseline likelihood of Cutaneous lupus erythematosus — no copies of the reported risk allele.

Source

Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus

Kunz M, König IR, Schillert A, Kruppa J, Ziegler A, Grallert H, Müller-Nurasyid M, Lieb W, Franke A, Ranki A, Panelius J, Koskenmies S

and 14 more — show all

Hasan T, Kere J, Rönn AC, Simon JC, Schmidt E, Wenzel J, Tüting T, Landsberg J, Zeller T, Blankenberg S, Gläser R, Patsinakidis N, Kuhn A, Ibrahim SM

Experimental dermatology · 2015 · PMID 25827949

Questions about rs3131060

What is rs3131060?

rs3131060 is a single position in the genome, in or near the FLOT1 gene. Published research associates it with cutaneous lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3131060 linked to?

On MyGeneLog this position is linked to Cutaneous Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs3131060 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3131060 come from?

GWAS Catalog, Experimental dermatology 2015, PMID:25827949. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cutaneous lupus erythematosus (rs3131060). MyGeneLog™. https://www.mygenelog.com/variants/rs3131060

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