0 311314123214Reads by AI crawlersClaude1ChatGPT3Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others14Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 400 European ancestry cases, 5,505 European ancestry controls; replicated in 249 European ancestry cases, 3,415 European ancestry controls.
The effect
Each copy of the A allele carried 5.64 times the odds of Myasthenia gravis (95% confidence interval 4.77-6.67); p = 2 × 10−90.
How common The A allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 7.5 kb from RNU6-1133P.
What each result means
A/ATwo copies of the version the research linked to Myasthenia gravis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Myasthenia gravis. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Myasthenia gravis. This is the starting point the study compared everyone against.
rs3130544 is a single position in the genome, in or near the MHC class I region gene. Published research associates it with myasthenia gravis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3130544 linked to?
On MyGeneLog this position is linked to Myasthenia Gravis. The research behind each link, and its sources, are set out on that condition page.
Does having rs3130544 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3130544 come from?
GWAS Catalog, Ann Neurol 2012, PMID:23055271. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 311314123214Reads by AI crawlersClaude1ChatGPT3Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others14Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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