Gene Knowledge Graph
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Feeling nervous

ZNF391 · rs3117425

Where this position leads

Condition: Irritable Mood

rs3117425 Condition: Irritable Mood Irritable Mood Condition rs3117425 rs3117425 ZNF391

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Feeling nervous — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling nervous.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling nervous compared to the general population.
Source
Item-level analyses reveal genetic heterogeneity in neuroticism
Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Nature communications · 2018 · PMID 29500382 · open access

Questions about rs3117425

What is rs3117425?

rs3117425 is a single position in the genome, in or near the ZNF391 gene. Published research associates it with feeling nervous. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3117425 linked to?

On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.

Does having rs3117425 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3117425 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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