PCSK6 · rs2898875
Where this position leads
Condition: Type 2 Diabetes
Strength of the evidence
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 74,124 European ancestry type 2 diabetes cases, 71,672 European ancestry headache cases, 1,112,725 European ancestry controls.
The effect The reported allele is G; the catalogue records no effect size ; p = 8 × 10−9.
Where it sits Chromosome 15, band 15q26.3 — in an intron of PCSK6.
rs2898875 is a single position in the genome, in or near the PCSK6 gene. Published research associates it with headache or type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Genes 2022, PMID:36292730. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Headache or type 2 diabetes (rs2898875). MyGeneLog™. https://www.mygenelog.com/variants/rs2898875