VKORC1 · rs2884737
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect Each copy of the C allele shifted the measure 0.01 % lower (95% confidence interval 0.01-0.01); p = 2 × 10−11.
Where it sits Chromosome 16, band 16p11.2 — in a non-coding transcript of VKORC1.
What ClinVar records
Classification
drug response for warfarin response - Dosage; reviewed by expert panel (3 of 4 stars, 1 submitter), last evaluated 2021-03-24.
ClinVar record 225983 NM_024006.6(VKORC1):c.173+324T>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2884737 is a single position in the genome, in or near the VKORC1 gene. Published research associates it with free cholesterol to total lipids in small hdl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
VKORC1 carries pharmacogenomic findings for Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Free Cholesterol to Total Lipids in Small HDL percentage (rs2884737). MyGeneLog™. https://www.mygenelog.com/variants/rs2884737