2 1612310Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3Others10Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,495,159 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0104 SD unit higher (95% confidence interval 0.0069-0.014); p = 1 × 10−8.
How common The T allele had a frequency of about 79% in the people studied.
Where it sits Chromosome 16, band 16q22.3 — in an intron of ZFHX3.
What each result means
G/GPublished research associates this genotype with typical/baseline likelihood of Refractive error — no copies of the reported risk allele.
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Refractive error.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Refractive error compared to the general population.
Nature genetics · 2026 · PMID 42009823 · open access
Questions about rs28533147
What is rs28533147?
rs28533147 is a single position in the genome, in or near the ZFHX3 gene. Published research associates it with refractive error. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28533147 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs28533147 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28533147 come from?
GWAS Catalog, Nature genetics 2026, PMID:42009823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 1612310Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3Others10Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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