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Monocyte count

near PCNPP2 · rs28450540

Where this position leads

What the study found

Who was studied 14,246 African American individuals, 686 East Asian ancestry individuals, 33,285 European American ancestry individuals, 13,585 Hispanic/Latin American individuals; replicated in 199,126 African ancestry, European ancestry, Hispanic or Latin American individuals.

The effect Each copy of the A allele shifted the measure 0.216 cell/L lower (95% confidence interval 0.18-0.26); p = 3 × 10⁻²⁵.

Where it sits Chromosome 9, band 9q22.1 — between genes, 49.7 kb from PCNPP2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Monocyte count compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Monocyte count.

C/C Published research associates this genotype with typical/baseline likelihood of Monocyte count — no copies of the reported risk allele.

Source

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program

Mikhaylova AV, McHugh CP, Polfus LM, Raffield LM, Boorgula MP, Blackwell TW, Brody JA, Broome J, Chami N, Chen MH, Conomos MP, Cox C

and 81 more — show all

Curran JE, Daya M, Ekunwe L, Glahn DC, Heard-Costa N, Highland HM, Hobbs BD, Ilboudo Y, Jain D, Lange LA, Miller-Fleming TW, Min N, Moon JY, Preuss MH, Rosen J, Ryan K, Smith AV, Sun Q, Surendran P, de Vries PS, Walter K, Wang Z, Wheeler M, Yanek LR, Zhong X, Abecasis GR, Almasy L, Barnes KC, Beaty TH, Becker LC, Blangero J, Boerwinkle E, Butterworth AS, Chavan S, Cho MH, Choquet H, Correa A, Cox N, DeMeo DL, Faraday N, Fornage M, Gerszten RE, Hou L, Johnson AD, Jorgenson E, Kaplan R, Kooperberg C, Kundu K, Laurie CA, Lettre G, Lewis JP, Li B, Li Y, Lloyd-Jones DM, Loos RJF, Manichaikul A, Meyers DA, Mitchell BD, Morrison AC, Ngo D, Nickerson DA, Nongmaithem S, North KE, O'Connell JR, Ortega VE, Pankratz N, Perry JA, Psaty BM, Rich SS, Soranzo N, Rotter JI, Silverman EK, Smith NL, Tang H, Tracy RP, Thornton TA, Vasan RS, Zein J, Mathias RA, Reiner AP, Auer PL

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

American journal of human genetics · 2021 · PMID 34582791

Questions about rs28450540

What is rs28450540?

rs28450540 is a single position in the genome, in or near the near PCNPP2 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs28450540 linked to?

On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.

Does having rs28450540 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28450540 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34582791. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Monocyte count (rs28450540). MyGeneLog™. https://www.mygenelog.com/variants/rs28450540

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