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Who was studied 244 European ancestry cases, 2,552 European ancestry controls, 56 African cases, 454 African controls, 85 Maghrebian cases, 261 Maghrebian controls.
The effect
Each copy of the C allele carried 3.03 times the odds of Childhood steroid-sensitive nephrotic syndrome (95% confidence interval 2.40-3.85); p = 4 × 10−20.
How common The C allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 2.1 kb from HLA-DRB1.
What each result means
C/CTwo copies of the version the research linked to Childhood steroid-sensitive nephrotic syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Childhood steroid-sensitive nephrotic syndrome. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Childhood steroid-sensitive nephrotic syndrome. This is the starting point the study compared everyone against.
Journal of the American Society of Nephrology : JASN · 2018 · PMID 29903748
Questions about rs28366266
What is rs28366266?
rs28366266 is a single position in the genome, in or near the HLA-DRB1 gene. Published research associates it with childhood steroid-sensitive nephrotic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28366266 linked to?
On MyGeneLog this position is linked to Childhood Steroid-Sensitive Nephrotic Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs28366266 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28366266 come from?
GWAS Catalog, J Am Soc Nephrol 2018, PMID:29903748. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 3423923312Reads by AI crawlersClaude0ChatGPT2Google · Gemini0Perplexity3Meta AI9Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others12Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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