Sensitive

Substance use disorder

SEMA6D · rs281280

Where this position leads

Condition: Substance Use Disorder

What the study found

Who was studied 1,458,999 European ancestry individuals, 58,370 mixed American ancestry individuals.

The effect Each copy of the A allele shifted the measure 8.41 lower; p = 4 × 10⁻¹⁷.

Where it sits Chromosome 15, band 15q21.1 — in an intron of SEMA6D.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Substance use disorder compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Substance use disorder.

G/G Published research associates this genotype with typical/baseline likelihood of Substance use disorder — no copies of the reported risk allele.

Source

Genome-wide meta-analyses of cross substance use disorders in diverse populations

Lai D, Zhang M, Green N, Abreu M, Schwantes-An TH, Parker CC, Zhang S, Jin F, Sun A, Zhang P, Edenberg HJ, Liu Y

and 1 more — show all

Foroud T

Molecular psychiatry · 2026 · PMID 41057643 · open access

Questions about rs281280

What is rs281280?

rs281280 is a single position in the genome, in or near the SEMA6D gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs281280 linked to?

On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs281280 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs281280 come from?

GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Substance use disorder (rs281280). MyGeneLog™. https://www.mygenelog.com/variants/rs281280

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