Gene Knowledge Graph
UTC
Standard

sodium (maximum, inv-norm transformed)

DPYD · rs2811198

Where this position leads

Drug: Fluoropyrimidines

rs2811198 Drug: Fluoropyrimidines Fluoropyrimidines Drug rs2811198 rs2811198 DPYD

What the study found

Who was studied 118,412 African American or Afro-Caribbean individuals, 57,401 Hispanic or Latin American individuals, 6,311 East Asian ancestry individuals, 421,132 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0249 lower (95% confidence interval 0.018-0.032); p = 6 × 10−13.

How common The A allele had a frequency of about 88% in the people studied.

Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD.

What each result means

A/A Two copies of the version the research linked to sodium (maximum, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to sodium (maximum, inv-norm transformed). That is a smaller link than two copies.
G/G No copy of the version the research linked to sodium (maximum, inv-norm transformed). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs2811198

What is rs2811198?

rs2811198 is a single position in the genome, in or near the DPYD gene. Published research associates it with sodium (maximum, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2811198 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2811198 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2811198 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

sodium (maximum, inv-norm transformed) (rs2811198). MyGeneLog™. https://www.mygenelog.com/variants/rs2811198

← See all variants