TRPS1 · rs2737205
Where this position leads
Condition: Age-Related Macular Degeneration
Strength of the evidence
Its strongest genetic-study result is p = 10−14, with 39 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 98,316 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0031 lower (95% confidence interval 0.0021-0.0041); p = 3 × 10−9.
How common The T allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 8, band 8q23.3 — in an intron of TRPS1.
How common each version is
CT
C 79.6% · T 20.4%
C 78.7% · T 21.3%
C 77.6% · T 22.4%
C 73.9% · T 26.1%
C 84.0% · T 16.0%
C 68.3% · T 31.7%
C 75.8% · T 24.2%
C 68.7% · T 31.3%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs2737205 is a single position in the genome, in or near the TRPS1 gene. Published research associates it with phosphatidylcholine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Phosphatidylcholine levels (rs2737205). MyGeneLog™. https://www.mygenelog.com/variants/rs2737205