A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic sclerosis compared to the general population. (GWAS Catalog, Genome Med 2018, PMID:30572963)
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic sclerosis. (GWAS Catalog, Genome Med 2018, PMID:30572963)
G/GPublished research associates this genotype with typical/baseline likelihood of Systemic sclerosis — no copies of the reported risk allele. (GWAS Catalog, Genome Med 2018, PMID:30572963)
Genome medicine · 2018 · PMID 30572963 · open access
Questions about rs2736346
What is rs2736346?
rs2736346 is a single position in the genome, in or near the BLK gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2736346 linked to?
On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs2736346 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2736346 come from?
GWAS Catalog, Genome Med 2018, PMID:30572963. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.