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Who was studied 182,798 British ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0208 lower; p = 5 × 10−10.
How common The A allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 4, band 4q24 — in an intron of PPA2.
What each result means
A/ATwo copies of the version the research linked to Fluid intelligence. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Fluid intelligence. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Fluid intelligence. This is the starting point the study compared everyone against.
Communications biology · 2026 · PMID 42092107 · open access
Questions about rs2726527
What is rs2726527?
rs2726527 is a single position in the genome, in or near the PPA2 gene. Published research associates it with fluid intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2726527 linked to?
On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.
Does having rs2726527 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2726527 come from?
GWAS Catalog, Communications biology 2026, PMID:42092107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 15121110Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple1China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others10Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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