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Subjective well-being (MTAG)

VRK2 · rs2678892

Where this position leads

Condition: Depression (Self-Reported Symptoms)

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁶, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 388,538 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0104 higher (95% confidence interval 0.0067-0.0141); p = 3 × 10⁻⁸.

How common The G allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 2, band 2p16.1 — in an intron of VRK2.

How common each version is

AG

Korean KRGDB

A 73.0% · G 27.0%

Korean Korea4K

A 74.9% · G 25.1%

Japanese ToMMo

A 71.3% · G 28.7%

World gnomAD

A 63.6% · G 36.4%

World 1000 Genomes

A 64.9% · G 35.1%

World TOPMed

A 63.8% · G 36.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A No copy of the version the research linked to Subjective well-being (MTAG). This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Subjective well-being (MTAG). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Subjective well-being (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multi-trait analysis of genome-wide association summary statistics using MTAG

Turley P, Walters RK, Maghzian O, Okbay A, Lee JJ, Fontana MA, Nguyen-Viet TA, Wedow R, Zacher M, Furlotte NA, Magnusson P, Oskarsson S

and 6 more — show all

Johannesson M, Visscher PM, Laibson D, Cesarini D, Neale BM, Benjamin DJ

23andMe Research Team · Social Science Genetic Association Consortium

Nature genetics · 2018 · PMID 29292387 · open access

Questions about rs2678892

What is rs2678892?

rs2678892 is a single position in the genome, in or near the VRK2 gene. Published research associates it with subjective well-being (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2678892 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.

Does having rs2678892 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2678892 come from?

GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Subjective well-being (MTAG) (rs2678892). MyGeneLog™. https://www.mygenelog.com/variants/rs2678892

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