Standard

Intelligence

TET2 · rs2454205

Where this position leads

Condition: Intelligence

rs2454205 Condition: Intelligence Intelligence Condition rs2454205 rs2454205 TET2

What the study found

Who was studied 269,867 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 8.45 z-score lower; p = 3 × 10−17.

Where it sits Chromosome 4, band 4q24 — in an intron of TET2.

What each result means

C/C No copy of the version the research linked to Intelligence. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Intelligence. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Intelligence. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs2454205

What is rs2454205?

rs2454205 is a single position in the genome, in or near the TET2 gene. Published research associates it with intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2454205 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs2454205 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2454205 come from?

GWAS Catalog, Nature genetics 2018, PMID:29942086. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intelligence (rs2454205). MyGeneLog™. https://www.mygenelog.com/variants/rs2454205

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