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Sensitive

Type 2 diabetes

PLEKHA1 · rs2421016

Where this position leads

Condition: Type 2 Diabetes

rs2421016 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs2421016 rs2421016 PLEKHA1

What the study found

Who was studied 6,353 South Asian ancestry cases, 7,179 South Asian ancestry controls, 3,871 European ancestry cases, 16,427 European ancestry controls, 34,840 cases, 114,981 controls; replicated in 7,888 South Asian ancestry cases, 20,679 South Asian ancestry controls, 387 European ancestry cases, 2,092 European ancestry controls, 19,998 East Asian ancestry cases, 30,983 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0564 lower (95% confidence interval 0.037-0.076); p = 2 × 10−8.

How common The T allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 10, band 10q26.13 — in an intron of PLEKHA1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Type 2 diabetes — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 2 diabetes.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 2 diabetes compared to the general population.
Source
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Zhao W, Rasheed A, Tikkanen E, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma S
and 78 more — show all
Imamura M, Yamauch T, Chambers JC, Chen P, Sapkota BR, Shah N, Jabeen S, Surendran P, Lu Y, Zhang W, Imran A, Abbas S, Majeed F, Trindade K, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood K, Ahmed N, Qureshi IH, Tanveer-Us-Salam, Iqbal W, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo X, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan S, Teo YY, Wang TD, Alam DS, Di Angelantonio E, Epstein S, Nielsen SF, Nordestgaard BG, Tybjaerg-Hansen A, Young R, Benn M, Frikke-Schmidt R, Kamstrup PR, Jukema JW, Sattar N, Smit R, Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti S, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa V, Rader DJ, Danesh J, Voight BF, Saleheen D
CHD Exome+ Consortium · EPIC-CVD Consortium · EPIC-Interact Consortium · Michigan Biobank
Nature genetics · 2017 · PMID 28869590 · open access

Questions about rs2421016

What is rs2421016?

rs2421016 is a single position in the genome, in or near the PLEKHA1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2421016 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs2421016 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2421016 come from?

GWAS Catalog, Nat Genet 2017, PMID:28869590. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants