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IgA nephropathy

HORMAD2 · rs2412971

Where this position leads

What the study found

Who was studied 1,194 Han Chinese ancestry cases, 902 Han Chinese ancestry controls, 1,553 European ancestry cases, 3,050 European ancestry controls; replicated in 2,491 East Asian ancestry cases, 1,780 East Asian ancestry controls, 2,420 European ancestry cases, 7,222 European ancestry controls.

The effect Each copy of the G allele carried 1.35 times the odds of IgA nephropathy; p = 6 × 10⁻¹¹.

How common The G allele had a frequency of about 67% in the people studied.

Where it sits Chromosome 22, band 22q12.2 — in an intron of HORMAD2.

What each result means

A/A No copy of the version the research linked to IgA nephropathy. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to IgA nephropathy. That is a smaller link than two copies.

G/G Two copies of the version the research linked to IgA nephropathy. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, Fasel D, Lata S, Prakash S, Shapiro S, Fischman C, Snyder HJ

and 80 more — show all

Appel G, Izzi C, Viola BF, Dallera N, Del Vecchio L, Barlassina C, Salvi E, Bertinetto FE, Amoroso A, Savoldi S, Rocchietti M, Amore A, Peruzzi L, Coppo R, Salvadori M, Ravani P, Magistroni R, Ghiggeri GM, Caridi G, Bodria M, Lugani F, Allegri L, Delsante M, Maiorana M, Magnano A, Frasca G, Boer E, Boscutti G, Ponticelli C, Mignani R, Marcantoni C, Di Landro D, Santoro D, Pani A, Polci R, Feriozzi S, Chicca S, Galliani M, Gigante M, Gesualdo L, Zamboli P, Battaglia GG, Garozzo M, Maixnerová D, Tesar V, Eitner F, Rauen T, Floege J, Kovacs T, Nagy J, Mucha K, Pączek L, Zaniew M, Mizerska-Wasiak M, Roszkowska-Blaim M, Pawlaczyk K, Gale D, Barratt J, Thibaudin L, Berthoux F, Canaud G, Boland A, Metzger M, Panzer U, Suzuki H, Goto S, Narita I, Caliskan Y, Xie J, Hou P, Chen N, Zhang H, Wyatt RJ, Novak J, Julian BA, Feehally J, Stengel B, Cusi D, Lifton RP, Gharavi AG

Nature genetics · 2014 · PMID 25305756 · open access

Questions about rs2412971

What is rs2412971?

rs2412971 is a single position in the genome, in or near the HORMAD2 gene. Published research associates it with iga nephropathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2412971 linked to?

On MyGeneLog this position is linked to IgA Nephropathy. The research behind each link, and its sources, are set out on that condition page.

Does having rs2412971 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2412971 come from?

GWAS Catalog, Nat Genet 2014, PMID:25305756. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

IgA nephropathy (rs2412971). MyGeneLog™. https://www.mygenelog.com/variants/rs2412971

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