Standard
IgA nephropathy
HORMAD2 · rs2412971
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of IgA nephropathy — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with IgA nephropathy.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of IgA nephropathy compared to the general population.
Source
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Kiryluk K,
Li Y,
Scolari F,
Sanna-Cherchi S,
Choi M,
Verbitsky M,
Fasel D,
Lata S,
Prakash S,
Shapiro S,
Fischman C,
Snyder HJ
and 80 more — show all
Appel G,
Izzi C,
Viola BF,
Dallera N,
Del Vecchio L,
Barlassina C,
Salvi E,
Bertinetto FE,
Amoroso A,
Savoldi S,
Rocchietti M,
Amore A,
Peruzzi L,
Coppo R,
Salvadori M,
Ravani P,
Magistroni R,
Ghiggeri GM,
Caridi G,
Bodria M,
Lugani F,
Allegri L,
Delsante M,
Maiorana M,
Magnano A,
Frasca G,
Boer E,
Boscutti G,
Ponticelli C,
Mignani R,
Marcantoni C,
Di Landro D,
Santoro D,
Pani A,
Polci R,
Feriozzi S,
Chicca S,
Galliani M,
Gigante M,
Gesualdo L,
Zamboli P,
Battaglia GG,
Garozzo M,
Maixnerová D,
Tesar V,
Eitner F,
Rauen T,
Floege J,
Kovacs T,
Nagy J,
Mucha K,
Pączek L,
Zaniew M,
Mizerska-Wasiak M,
Roszkowska-Blaim M,
Pawlaczyk K,
Gale D,
Barratt J,
Thibaudin L,
Berthoux F,
Canaud G,
Boland A,
Metzger M,
Panzer U,
Suzuki H,
Goto S,
Narita I,
Caliskan Y,
Xie J,
Hou P,
Chen N,
Zhang H,
Wyatt RJ,
Novak J,
Julian BA,
Feehally J,
Stengel B,
Cusi D,
Lifton RP,
Gharavi AG
Nature genetics · 2014 · PMID 25305756 · open access
Questions about rs2412971
What is rs2412971?
rs2412971 is a single position in the genome, in or near the HORMAD2 gene. Published research associates it with iga nephropathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs2412971 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2412971 come from?
GWAS Catalog, Nat Genet 2014, PMID:25305756. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants