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Who was studied 98,316 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.00689 higher (95% confidence interval 0.0047-0.0091); p = 4 × 10−10.
How common The T allele had a frequency of about 38% in the people studied.
Where it sits Chromosome 1, band 1q25.2 — between genes, 26.3 kb from MIR4424.
What each result means
G/GNo copy of the version the research linked to Phospholipids in HDL. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Phospholipids in HDL. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Phospholipids in HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
Ophthalmology science · 2024 · PMID 39091897 · open access
Questions about rs2248666
What is rs2248666?
rs2248666 is a single position in the genome, in or near the near MIR4424 gene. Published research associates it with phospholipids in hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2248666 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does having rs2248666 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2248666 come from?
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Phospholipids in HDL (rs2248666). MyGeneLog™. https://www.mygenelog.com/variants/rs2248666