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Serum metabolite levels

ABCG2 · rs2231137

Where this position leads

What the study found

Who was studied 3,926 Hispanic/Latino individuals.

The effect Each copy of the C allele shifted the measure 0.244 higher (95% confidence interval 0.19-0.3); p = 5 × 10⁻²⁰.

How common The C allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 4, band 4q22.1 — a missense change in ABCG2.

What ClinVar records

Classification Benign for BLOOD GROUP, JUNIOR SYSTEM, URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 1, ABCG2-related disorder; criteria provided, single submitter (1 of 4 stars, 3 submitters), last evaluated 2024-11-26. ClinVar record 30386 NM_004827.3(ABCG2):c.34G>A (p.Val12Met)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version the research linked to Serum metabolite levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Serum metabolite levels. That is a smaller link than two copies.

T/T No copy of the version the research linked to Serum metabolite levels. This is the starting point the study compared everyone against.

Source

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos

Feofanova EV, Chen H, Dai Y, Jia P, Grove ML, Morrison AC, Qi Q, Daviglus M, Cai J, North KE, Laurie CC, Kaplan RC

and 2 more — show all

Boerwinkle E, Yu B

American journal of human genetics · 2020 · PMID 33031748

Questions about rs2231137

What is rs2231137?

rs2231137 is a single position in the genome, in or near the ABCG2 gene. Published research associates it with serum metabolite levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2231137 affect how medicines work?

ABCG2 carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2231137 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2231137 come from?

GWAS Catalog, Am J Hum Genet 2020, PMID:33031748. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum metabolite levels (rs2231137). MyGeneLog™. https://www.mygenelog.com/variants/rs2231137

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