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Primary open angle glaucoma (PheCode 365.11)

near LTBP2 · rs2165198

Where this position leads

Condition: Glaucoma

rs2165198 Condition: Glaucoma Glaucoma Condition rs2165198 rs2165198 near LTBP2

What the study found

Who was studied 13,552 African American or Afro-Caribbean cases, 105,042 African American or Afro-Caribbean controls, 2,857 Hispanic or Latin American cases, 56,071 Hispanic or Latin American controls, 312 East Asian ancestry cases, 6,452 East Asian ancestry controls, 20,091 European ancestry cases, 424,364 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0639 lower (95% confidence interval 0.048-0.08); p = 2 × 10−13.

How common The A allele had a frequency of about 52% in the people studied.

Where it sits Chromosome 14, band 14q24.3 — between genes, 0.7 kb from LTBP2.

What each result means

A/A Two copies of the version the research linked to Primary open angle glaucoma (PheCode 365.11). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Primary open angle glaucoma (PheCode 365.11). That is a smaller link than two copies.
T/T No copy of the version the research linked to Primary open angle glaucoma (PheCode 365.11). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs2165198

What is rs2165198?

rs2165198 is a single position in the genome, in or near the near LTBP2 gene. Published research associates it with primary open angle glaucoma (phecode 365.11). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2165198 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs2165198 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2165198 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Primary open angle glaucoma (PheCode 365.11) (rs2165198). MyGeneLog™. https://www.mygenelog.com/variants/rs2165198

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