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Feeling guilty

PRKCA · rs2109648

Where this position leads

Condition: Irritable Mood

rs2109648 Condition: Irritable Mood Irritable Mood Condition rs2109648 rs2109648 PRKCA

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling guilty compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling guilty.
G/G Published research associates this genotype with typical/baseline likelihood of Feeling guilty — no copies of the reported risk allele.
Source
Item-level analyses reveal genetic heterogeneity in neuroticism
Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Nature communications · 2018 · PMID 29500382 · open access

Questions about rs2109648

What is rs2109648?

rs2109648 is a single position in the genome, in or near the PRKCA gene. Published research associates it with feeling guilty. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2109648 linked to?

On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.

Does having rs2109648 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2109648 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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