3 401235223220Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity3Meta AI5Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total40Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,277 European ancestry cases, 1,488 European ancestry controls; replicated in 1,365 European ancestry cases, 1,396 European ancestry controls.
The effect
Each copy of the G allele carried 1.46 times the odds of Crohn's disease; p = 3 × 10−10.
Where it sits Chromosome 16, band 16q12.1 — in an intron of NOD2.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-06-18.
ClinVar record 1261773NM_001370466.1(NOD2):c.2717+265A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2076756 is a single position in the genome, in or near the NOD2 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2076756 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs2076756 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2076756 come from?
GWAS Catalog, Gut 2012, PMID:22936669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 401235223220Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity3Meta AI5Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others20Total40Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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