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Who was studied 4,738 European ancestry female cases, 436,834 European ancestry female controls.
The effect
Each copy of the T allele carried 1.15 times the odds of Intrahepatic cholestasis of pregnancy (95% confidence interval 1.1-1.2); p = 1 × 10−10.
How common The T allele had a frequency of about 57% in the people studied.
Where it sits Chromosome 14, band 14q32.2 — in an intron of CCDC85C.
What each result means
C/CNo copy of the version the research linked to Intrahepatic cholestasis of pregnancy. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Intrahepatic cholestasis of pregnancy. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Intrahepatic cholestasis of pregnancy. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2026 · PMID 42178310 · open access
Questions about rs2021095
What is rs2021095?
rs2021095 is a single position in the genome, in or near the CCDC85C gene. Published research associates it with intrahepatic cholestasis of pregnancy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2021095 linked to?
On MyGeneLog this position is linked to Intrahepatic Cholestasis of Pregnancy. The research behind each link, and its sources, are set out on that condition page.
Does having rs2021095 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2021095 come from?
GWAS Catalog, Nature communications 2026, PMID:42178310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Intrahepatic cholestasis of pregnancy (rs2021095). MyGeneLog™. https://www.mygenelog.com/variants/rs2021095