Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor
CYP3A5 · rs188845491
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Who was studied 1,794 European ancestry cases, 18 African and Asian ancestry cases; replicated in 1,922 European ancestry cases, 19 African and Asian ancestry cases.
The effect
Each copy of the C allele shifted the measure 0.495 higher (95% confidence interval 0.36-0.63); p = 3 × 10−12.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 7, band 7q22.1 — in an intron of CYP3A7-CYP3A51P.
What each result means
C/CTwo copies of the version the research linked to Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. This is the starting point the study compared everyone against.
rs188845491 is a single position in the genome, in or near the CYP3A5 gene. Published research associates it with ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs188845491 linked to?
On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs188845491 affect how medicines work?
CYP3A5 carries pharmacogenomic findings for Tacrolimus. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs188845491 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs188845491 come from?
GWAS Catalog, Eur Heart J 2015, PMID:25935875. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 494225222228Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity2Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others28Total49Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor (rs188845491). MyGeneLog™. https://www.mygenelog.com/variants/rs188845491