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Depressive symptoms (MTAG)

NOS1 · rs1875140

Where this position leads

Condition: Depression (Self-Reported Symptoms)

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 354,862 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0151 higher (95% confidence interval 0.0098-0.0204); p = 2 × 10⁻⁸.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 12, band 12q24.22 — in an intron of NOS1.

How common each version is

CT

Korean KRGDB

C 37.2% · T 62.8%

Korean Korea4K

C 37.5% · T 62.5%

Korean Korea1K

C 37.3% · T 62.7%

Japanese ToMMo

C 45.4% · T 54.6%

Vietnamese

C 39.7% · T 60.3%

World gnomAD

C 26.0% · T 74.0%

World 1000 Genomes

C 31.2% · T 68.8%

World TOPMed

C 26.7% · T 73.3%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Depressive symptoms (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Depressive symptoms (MTAG). That is a smaller link than two copies.

T/T No copy of the version the research linked to Depressive symptoms (MTAG). This is the starting point the study compared everyone against.

Source

Multi-trait analysis of genome-wide association summary statistics using MTAG

Turley P, Walters RK, Maghzian O, Okbay A, Lee JJ, Fontana MA, Nguyen-Viet TA, Wedow R, Zacher M, Furlotte NA, Magnusson P, Oskarsson S

and 6 more — show all

Johannesson M, Visscher PM, Laibson D, Cesarini D, Neale BM, Benjamin DJ

23andMe Research Team · Social Science Genetic Association Consortium

Nature genetics · 2018 · PMID 29292387 · open access

Questions about rs1875140

What is rs1875140?

rs1875140 is a single position in the genome, in or near the NOS1 gene. Published research associates it with depressive symptoms (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1875140 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.

Does having rs1875140 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1875140 come from?

GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depressive symptoms (MTAG) (rs1875140). MyGeneLog™. https://www.mygenelog.com/variants/rs1875140

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